The Trynka Group at the Wellcome Sanger Institute

    Immune Genomics Group

    Trynka Group

    We investigate how genetic variation shapes immune cell function and contributes to human disease, connecting genetic associations to mechanisms and opportunities for therapeutic discovery.

    Research

    Project JAGUAR artwork

    Single-cell eQTL mapping in dynamic immune states

    We map context-specific genetic effects on gene regulation in resting and stimulated immune cells, including work through Project JAGUAR to study immune gene regulation across Latin American populations and address representation gaps in genomic data.

    Illustration of CRISPR-Cas9 gene editing

    CRISPR perturbation of immune disease-associated genes

    Pooled and arrayed CRISPR screens in primary immune cells let us define the causal gene functions that underlie immune-mediated diseases.

    High-content microscopy image of Jurkat cells

    High-content imaging of cellular phenotypes

    High-throughput imaging quantifies morphological and functional features at the single-cell level, which we integrate with transcriptomic data to connect cell phenotype to gene regulation.